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Von Hippel Lindau polyclonal antibody

货号: BS62268

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS62268

Product Name :Von Hippel Lindau polyclonal antibody

Swiss-Prot :P40337

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Von Hippel Lindau polyclonal antibody detects endogenous levels of Von Hippel Lindau protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Hypoxia Signaling,

Alternative Name :Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL; VHL

Immunogen :Synthetic peptide, corresponding to Human Von Hippel Lindau.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Von Hippel Lindau polyclonal antibody at 1:500 dilution LaneA:C6 whole cell lysate LaneB:H1792 whole cell lysate LaneC:HEK293T whole cell lysate