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PTP1B polyclonal antibody

货号: BS62264

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62264

Product Name :PTP1B polyclonal antibody

Swiss-Prot :P18031

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is areversible process, involving both enzymes that phosphorylate proteins ontyrosine residues as well as a rapidly expanding family of protein tyrosinephosphatases. These latter enzymes bear little resemblance to either theprotein serine and protein threonine phosphatases or to the acid and alkalinephosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein of approximately 40 kDa molecular weight. On the basis of sequence analysis, PTP1B expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, ahomolog of the neural adhesion molecule (NCAM). PTPase 1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PTP1B polyclonal antibody detects endogenous levels of PTP1B protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; PTP1B

Immunogen :Synthetic peptide, corresponding to Human PTP1B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PTP1B polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:MCF-7 whole cell lysate LaneC:A549 whole cell lysate LaneD:HEK293T whole cell lysate LaneE:The Lung tissue lysate of Mouse

Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway

JournalEvidence-based Complementary and Alternative Medicine

ApplicationWB

IF1.813

SpeciesRat

PMID29479370