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Paxillin polyclonal antibody

货号: BS62253

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62253

Product Name :Paxillin polyclonal antibody

Swiss-Prot :P49023

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix. Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization. Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118. Phospho-Paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Paxillin polyclonal antibody detects endogenous levels of Paxillin protein.

BiowMW :~ 64 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Paxillin; PXN

Immunogen :Synthetic peptide, corresponding to Human Paxillin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Paxillin polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:HGC27 whole cell lysate LaneC:The Kidney tissue lysate of Rat

Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells

JournalInternational Journal of Clinical and Experimental Pathology

ApplicationWB

IF0.205

SpeciesHuman

PMID25337216