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KDM1A polyclonal antibody

货号: BS6189

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6189

Product Name :KDM1A polyclonal antibody

Swiss-Prot :O60341

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:100 IF: 1:50~1:100

Background :Lysine-specific histone demethylase 1 (LSD1), also designated BHC110, is a flavin-dependent amine oxidase which catalyzes the removal of one or two methyl groups from the methyl-lysine-4 side chain of Histone H3. The LSD1 protein contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. Association with CoREST, a SANT domain-containing corepressor, positively regulates LSD1. CoREST mediates the demethylation ability of LSD1 and protects it from proteasomal degradation in vivo.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :KDM1A polyclonal antibody detects endogenous levels of KDM1A protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Epigenetic Writers and Erasers of Histone H3,

Alternative Name :Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2; KDM1A; AOF2; KDM1; KIAA0601; LSD1

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 365-515 of human KDM1 (NP_055828.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using KDM1 antibody at 1:1000 dilution.

Western blot analysis of extracts from normal (control) and KDM1 pAb knockout (KO) 293T cells, using KDM1 pAb antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded rat spleen using KDM1 antibody at dilution of 1:100 (40x lens).

Immunofluorescence analysis of HeLa cells using KDM1 Polyclonal Antibody at dilution of 1:100 (40x lens).