产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

PINK1 polyclonal antibody

货号: BS61826

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61826

Product Name :PINK1 polyclonal antibody

Swiss-Prot :Q9BXM7

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:2000

Background :PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria. PINK1 phosphorylates Parkin and promotes its translocation to mitochondria. Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PINK1 pAb detects endogenous levels of PINK1 protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1; PINK1

Immunogen :Synthetic peptide, corresponding to Human PINK1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PINK1 pAb at 1:2000 dilution Lane1:L02 whole cell lysate(40ug) Lane2:A2780 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug)

Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation

JournalOxidative Medicine and Cellular Longevity

ApplicationWB

IF6.543

SpeciesHuman

PMID34306311
Insulin alleviates mitochondrial oxidative stress involving upregulation of superoxide dismutase 2 and uncoupling protein 2 in septic acute kidney injury

JournalExperimental and Therapeutic Medicine

ApplicationIHC

IF2.447

SpeciesRat

PMID29563990