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NDFIP1 polyclonal antibody

货号: BS61770

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61770

Product Name :NDFIP1 polyclonal antibody

Swiss-Prot :Q9BT67

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Nedd4 family interacting protein-1 (Ndfip1), also referred to as N4WBP5, is a member of a family of highly conserved proteins. It has three transmembrane domains in its carboxy terminal and two PY motifs in its amino terminal. Ndfip1 is a 221 amino acid, Golgi-associated protein that may play a role in Golgi structure and function. Ndfip1 binds the WW domains of a number of Nedd4 family members called HECT-type E3 ubiquitin ligases. Ndfip1 is strongly expressed in surviving neurons around a site of injury. This suggests that ubiquitination may be a possible survival strategy and Ndfip1 may act as a neuroprotective protein. Ndfip1 may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of Ndfip1 and its association with Itch may be promoted by T cell activation. Mice lacking Ndfip1 exhibit inactivation of Itch and accumulation of JunB causing them to die prematurely with severe skin and lung inflammation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NDFIP1 polyclonal antibody detects endogenous levels of NDFIP1 protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein; NDFIP1; N4WBP5; PSEC0192; PSEC0223

Immunogen :Synthetic peptide, corresponding to amino acids 170-220 of Human NDFIP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of NDFIP1 polyclonal antibody at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:AML-12 whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)