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Caspase-4 polyclonal antibody

货号: BS61766

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61766

Product Name :Caspase-4 polyclonal antibody

Swiss-Prot :P49662/P51878

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Caspase-4 (TX/ICH-2/ICErelII) is a member of the caspase family of proteases that play a key role in the execution of apoptosis and activation of inflammatory cytokines. Expression of caspase-4 has been observed in most tissues except brain, with highest levels in placenta, lung, spleen, and peripheral blood lymphocytes (PBL). Caspase-4 was originally found to contribute to Fas-mediated apoptosis. Several caspases (including caspase-4, caspase-5, and mouse caspase-11 and -12) are most closely related to caspase-1 and are capable of inducing apoptosis when over-expressed but are better characterized in the proteolytic activation of inflammatory cytokines. Caspase-4 associates with TRAF6 and is involved in the LPS inducible production of inflammatory cytokines IL-8 and MIP1 in THP-1 cells. While caspase-4 and mouse caspase-12 localize to the endoplasmic reticulum (ER) and may be activated by drugs that induce ER-stress, at least one study suggests that caspase-4 and caspase-12 are not essential for the ER-stress induced apoptosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caspase-4 polyclonal antibody detects endogenous levels of Caspase-4 protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inflammasonme Signaling,Necrotic Cell Death,

Alternative Name :Caspase4; Caspase 4; CASP-4; ICE and Ced-3 homolog 2; ICH-2; ICE(rel)-II; Mih1; Protease TX; Caspase-4 subunit 1; Caspase-4 subunit 2; CASP4; ICH2; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY; Caspase-5 subunit p20; Caspase-5 subunit p10; CASP5; ICH3

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human Caspase-4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Caspase-4 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:U-87MG whole cell lysate(40ug) Lane4:AML-12 whole cell lysate(10ug) Lane5:PC12 whole cell lysate(40ug)