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RFWD3 polyclonal antibody

货号: BS61764

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61764

Product Name :RFWD3 polyclonal antibody

Swiss-Prot :Q6PCD5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RFWD3 polyclonal antibody detects endogenous levels of RFWD3 protein.

BiowMW :~ 85 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3; RFWD3; RNF201

Immunogen :Synthetic peptide, corresponding to amino acids 380-430 of Human RFWD3 .

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RFWD3 polyclonal antibody at 1:500 dilution Lane1:K562 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:H9C2 whole cell lysate(40ug) Lane4:SP2/0 whole cell lysate(40ug)