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CDC14A polyclonal antibody

货号: BS61750

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61750

Product Name :CDC14A polyclonal antibody

Swiss-Prot :Q9UNH5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :In budding yeast, the Cdc14a phosphatase activates mitotic exit by dephosphorylation of specific cyclin-dependent kinase (Cdk) substrates and seems to be regulated by sequestration in the nucleolus until its release during mitosis. Human Cdc14a phosphatase is highly similar to Saccharomyces cerevisiae Cdc14 and is a member of the dual specificity protein Tyrosine phosphatase family. It interacts with and dephosphorylates tumor suppressor protein p53 and may regulate the function of p53. In addition, Cdc14a dephosphorylates hCdh1 and activates APCCdh1. Cdc14a phosphatase plays a role in the regulation of the centrosome cycle, mitosis and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. Deregulated human Cdc14a phosphatase disrupts centrosome separation and chromosome segregation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CDC14A polyclonal antibody detects endogenous levels of CDC14A protein.

BiowMW :~ 66 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A; CDC14A

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human CDC14A.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CDC14A polyclonal antibody at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:MEF whole cell lysate(40ug) Lane3:K562 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)