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MYLIP polyclonal antibody

货号: BS61709

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61709

Product Name :MYLIP polyclonal antibody

Swiss-Prot :Q8WY64

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MYLIP polyclonal antibody detects endogenous levels of MYLIP protein.

BiowMW :~ 49 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR; RING-type E3 ubiquitin transferase MYLIP; MYLIP; BZF1; IDOL; BM-023; PP5242

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human MYLIP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MYLIP polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:COS-7 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)