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KCNQ5 polyclonal antibody

货号: BS61680

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61680

Product Name :KCNQ5 polyclonal antibody

Swiss-Prot :Q9NR82

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Voltage-gated K+ channels in the plasma membrane control the repolarization and frequency of action potentials in neurons, muscles and other excitable cells. KCNQ proteins contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells. KCNQ5 expression is highest in the brain and muscle. Out of the three splice variants of KCNQ5, the longest variant, KCNQ5 type III, is the predominant form expressed in skeletal muscle. The gene encoding human KCNQ5 maps to chromosome 6q13. Mutations in the gene encoding KCNQ2, but not in the gene encoding KCNQ5, lead to benign familial neonatal convulsions, while mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling. Mutations in KCNQ4 are implicated in the onset of deafness.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :KCNQ5 polyclonal antibody detects endogenous levels of KCNQ5 protein.

BiowMW :~ 102 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Potassium voltage-gated channel subfamily KQT member 5; KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5; KCNQ5

Immunogen :Synthetic peptide, corresponding Human KCNQ5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of KCNQ5 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:COS-7 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)