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IQGAP3 polyclonal antibody

货号: BS61643

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61643

Product Name :IQGAP3 polyclonal antibody

Swiss-Prot :Q86VI3

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, 4 IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IQGAP3 polyclonal antibody detects endogenous levels of IQGAP3 protein.

BiowMW :~ 185 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ras GTPase-activating-like protein IQGAP3; IQGAP3

Immunogen :Synthetic peptide, corresponding Human IQGAP3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IQGAP3 polyclonal antibody at 1:500 dilution Lane1:BV2 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug)