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Catenin-β polyclonal antibody

货号: BS61637

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61637

Product Name :Catenin-β polyclonal antibody

Swiss-Prot :P35222

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CTNB1 polyclonal antibody detects endogenous levels of CTNB1 protein.

BiowMW :~ 92 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :G Protein-coupled Receptors Signaling to MAPK Erk,Cell Cycle G2 M DNA Damage Signaling Pathway,

Alternative Name :Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; OK/SW-cl.35; PRO2286; CTNB1

Immunogen :Synthetic peptide, corresponding Human CTNB1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CTNB1 polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)

Angiogenin interacts with ribonuclease inhibitor regulating PI3K/AKT/mTOR signaling pathway in bladder cancer cells

JournalCellular Signalling

ApplicationWB

IF3.968

SpeciesHuman

PMID25193113