Product Name :CDK5RAP3 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :CDK5RAP3 (cyclin dependent kinase 5 regulatory subunit-associated protein 3), also designated C53 or IC53, may be involved in neuronal differentiation, cell proliferation and DNA repair. The role CDK5RAP3 plays in neuronal differentiation may be attributed to its interaction with the Cdk5 activator protein called p35. p35 physically associates with Cdk5 to activate enzymatic activity. Cdk5 activity increases significantly during neuronal differentiation. Upon transfection, CDK5RAP3 is capable of increasing the rate of cell proliferation, suggesting that it may play a role in tumorigenesis. CDK5RAP3 is a regulatory component of the G2/M DNA damage checkpoint in response to genotoxic stress. CDK5RAP3 is expressed in brain, heart, placenta, liver, skeletal muscle, lung, kidney and pancreas and is overexpressed in tumor tissue. Three named isoforms exist for CDK5RAP3 as a result of alternative splicing events. CDK5RAP3 contains two leucine zipper motifs, putative phosphorylation and potential N-myristoylation sites.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CDK5RAP3 polyclonal antibody detects endogenous levels of CDK5RAP3 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; Protein HSF-27
Immunogen :Synthetic peptide, corresponding to amino acids 211-255 of Human CDK5RAP3.
Modification :Unmodification
