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IKZF3 polyclonal antibody

货号: BS61559

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61559

Product Name :IKZF3 polyclonal antibody

Swiss-Prot :Q9UKT9

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Aiolos is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family members. Multiple Aiolos isoforms are generated through alternative splicing of the portion of the transcript encoding the amino-terminal zinc fingers. Aiolos is expressed by lymphoid tissues, with highest expression levels seen in mature B and T cells. Ikaros family proteins control lymphocyte development by recruiting chromatin remodeling complexes to DNA. B cells from mice lacking Aiolos have a reduced threshold for activation, increased proliferation, and elevated levels of IgG and IgE. In addition, Aiolos null mice develop B cell lymphomas. In T cells, Aiolos contributes to Th17 cell differentiation by suppressing IL-2 expression. Aberrant expression of Aiolos in transformed epithelial cells promotes anchorage independence through downregulation of adhesion-related genes. Alterations in the Aiolos gene are observed in near haploid acute lymphoblastic leukemia, and the genetic locus containing Aiolos is linked to increased susceptibility to rheumatoid arthritis and systemic lupus erythematosus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IKZF3 polyclonal antibody detects endogenous levels of IKZF3 protein.

BiowMW :~ 50, 58, 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,

Alternative Name :Zinc finger protein Aiolos; Ikaros family zinc finger protein 3

Immunogen :Synthetic peptide, corresponding to amino acids 363-407 of Human IKZF3

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IKZF3 polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug)

免疫沉淀（IP）

免疫组织化学（IHC）