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AVEN polyclonal antibody

货号: BS61525

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61525

Product Name :AVEN polyclonal antibody

Swiss-Prot :Q9NQS1

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Bcl-2 family regulates apoptosis in response to a wide range of stimuli through control of mitochondrial cytochrome c release and caspase activation. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. A large number of proteins have been found to interact with Bcl-2 and other family members that have been shown to help regulate apoptosis. Aven was identified in a yeast two-hybrid screen as a bcl-xL interacting protein. It also interacts with other anti-apoptotic family members, including Bcl-2, but fails to interact with pro-apopotic proteins Bax and Bak. Aven inhibits apoptosis and enhances anti-apopotic activity of Bcl-xL. It interferes with association with Apaf-1 and activation of caspase-9. Aven overexpression is associated with poor prognosis in acute lymphoblastic leukemia.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AVEN polyclonal antibody detects endogenous levels of AVEN protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell death regulator Aven

Immunogen :Synthetic peptide, corresponding to amino acids 318-362 of Human AVEN.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AVEN polyclonal antibody at 1:500 dilution Lane1:Hct-116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:L02 whole cell lysate(40ug) Lane4:The testis tissue lysate of Mouse(40ug) Lane5:The testis tissue lysate of Rat(40ug)