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TNNT2 polyclonal antibody

货号: BS61520

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61520

Product Name :TNNT2 polyclonal antibody

Swiss-Prot :P45379

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Troponin, working in conjunction with tropomyosin, functions as a molecular switch that regulates muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). In response to β-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC .

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TNNT2 polyclonal antibody detects endogenous levels of TNNT2 protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Troponin T, cardiac muscle;TnTc;Cardiac muscle troponin T;cTnT

Immunogen :Synthetic peptide, corresponding to amino acids 149-193 of Human TNNT2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TNNT2 polyclonal antibody at 1:500 dilution Lane1:The heart tissue lysate of Mouse(40ug) Lane2:The heart tissue lysate of Rat(40ug) Lane3:The fetal heart tissue lysate of Mouse(40ug)