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SETMAR polyclonal antibody

货号: BS61494

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61494

Product Name :SETMAR polyclonal antibody

Swiss-Prot :Q53H47

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :SETMAR (SET domain and mariner transposase fusion gene-containing protein), also known as METNASE or Hsmar1, is a ubiquitously expressed fusion protein with histone-lysine N-methyltransferase activity and DNA-binding, DNA-looping and DNA-cleavage activities. Localizing to the nucleus, SETMAR contains one N-terminal SET domain which facilitates the histone-lysine methyltransferase activity (at H3-Lys4 and H3-Lys36) and a C-terminal transposase domain which is responsible for the DNA-binding, -looping and -cleavage activities. Both domains are essential for the proper function of SETMAR. SETMAR specifically functions in DNA repair but, on its own, SETMAR can only bind to 5’-TIR (terminal inverted repeats) in DNA. For interactions with non-TIR DNA, SETMAR (via its SET domain) binds to and forms a stable complex with the pre-mRNA processing protein PRP19. Due to alternative splicing events, two isoforms exist.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SETMAR polyclonal antibody detects endogenous levels of SETMAR protein.

BiowMW :~ 78 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion protein; Metnase; Histone-lysine N-methyltransferase; Transposon Hsmar1 transposase; SETMAR

Immunogen :Synthetic peptide, corresponding to amino acids 349-394 of Human SETMAR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SETMAR polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:NIH-3T3 whole cell lysate(40ug)