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PEA15 polyclonal antibody

货号: BS61435

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61435

Product Name :PEA15 polyclonal antibody

Swiss-Prot :Q15121

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :PEA-15 (Phosphoprotein Enriched in Astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 colocalizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, Phosphoprotein Enriched in Diabetes, for its elevated expression in type 2 diabetic patients.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PEA15 polyclonal antibody detects endogenous levels of PEA15 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED; PEA15

Immunogen :Synthetic peptide, corresponding to amino acids 85-130 of Human PEA15.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PEA15 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(30ug) Lane2:H9C2 whole cell lysate(30ug) Lane3:RAW264.7 whole cell lysate(30ug) Lane4:HEK293T whole cell lysate(30ug)