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TSC2 polyclonal antibody

货号: BS61351

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61351

Product Name :TSC2 polyclonal antibody

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrinradixin-moesin (ERM) family of Actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart and kidney.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TSC2 pAb detects endogenous levels of TSC2 protein.

BiowMW :~ 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling,Insulin &Glucose Signaling,MTOR signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Immunogen :Synthetic peptide, corresponding Human TSC2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TSC2 pAb at 1:500 dilution Lane1:Myla2059 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:The Brain tissue lysate of Rat(40ug) Lane4:AML-12 whole cell lysate(40ug)

Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy

JournalHepatology Research

ApplicationIHC

IF4.288

SpeciesHuman

PMID