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IL13RA2 polyclonal antibody

货号: BS61342

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61342

Product Name :IL13RA2 polyclonal antibody

Swiss-Prot :Q14627

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL13RA2 polyclonal antibodydetects endogenous levels of IL13RA2 protein.

BiowMW :~ 37 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein; CD213a2; IL13RA2; IL13R

Immunogen :A synthetic peptide corresponding to residues 251-296 in Human IL13RA2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of IL13RA2 polyclonal antibodyat 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:The liver tissue lysate of Mouse(30ug) Lane3:The liver tissue lysate of Rat(30ug)