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SRD5A1 polyclonal antibody

货号: BS61336

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61336

Product Name :SRD5A1 polyclonal antibody

Swiss-Prot :P18405

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Steroid 5α-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5α-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5α-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5α-Reductase 1 is expressed in all portions of the hair follicle, whereas 5α-Reductase 2 is expressed only in mesenchymal portions. In addition, 5α-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5α-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5α-Reductase-3α-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SRD5A1 polyclonal antibody detects endogenous levels of SRD5A1 protein.

BiowMW :~ 29 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22); SR type 1; Steroid 5-alpha-reductase 1; S5AR 1; SRD5A1

Immunogen :A synthetic peptide corresponding to residues in Human SRD5A1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SRD5A1 polyclonal antibody at 1:500 dilution Line1:HEK293T whole cell lysate Line2:H9C2 whole cell lysate Line3:Raw264.7 whole cell lysate

Intronic miR-140-5p contributes to beta-cypermethrin-mediated testosterone decline

JournalScience Of The Total Environment

ApplicationWB

IF7.963

SpeciesRat,Mouse

PMID34794910