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MAP3K4 polyclonal antibody

货号: BS61073

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61073

Product Name :MAP3K4 polyclonal antibody

Swiss-Prot :Q9Y6R4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 has been shown to phosphorylate MEK-1 via Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK path-way. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MAP3K4 polyclonal antibody detects endogenous levels of MAP3K4 protein.

BiowMW :~ 182 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :Mitogen-activated protein kinase kinase kinase 4; MAP three kinase 1; MEK kinase 4; MEKK 4; MAP3K4

Immunogen :A synthetic peptide corresponding to residues in Human MAP3K4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MAP3K4 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:HEK293T whole cell lysate Lane3:PC12 whole cell lysate Lane4:SP20 whole cell lysate Lane5:H9C2 whole cell lysate Lane6:Raw264.7 whole cell lysate