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MED12 polyclonal antibody

货号: BS61060

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61060

Product Name :MED12 polyclonal antibody

Swiss-Prot :Q93074

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, that are characterized by the presence of a nuclear receptor recognition motif which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MED12 polyclonal antibody detects endogenous levels of MED12 protein.

BiowMW :~ 243 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Mediator of RNA polymerase II transcription subunit 12; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Trap230; Trinucleotide repeat-containing gene 11 protein; MED12

Immunogen :A synthetic peptide corresponding to residues in Human MED12.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MED12 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:H9C2 whole cell lysate Lane3:sp20 whole cell lysate Lane4:PC12 whole cell lysate