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PPP1R13B polyclonal antibody

货号: BS60843

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60843

Product Name :PPP1R13B polyclonal antibody

Swiss-Prot :Q96KQ4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :ASPP proteins interact with p53 and are responsible for enhancing p53-induced apoptosis but not cell cycle arrest. Inhibition of endogenous ASPP1 (PPP1R13B) function inhibits the apoptotic function of endogenous p53 in response to apoptotic stimuli. ASPP1 amplifies DNA binding and transactivation function of p53 on the promoters of proapoptotic genes in vivo. Expres-sion of ASPP1 is often downregulated in human breast carcinomas expressing wildtype p53, but not in those expressing mutant p53. This research indicates that ASPP1 regulates the tumor suppression function of p53 in vivo. ASPP1 is predominantly a cytoplasmic protein, although some fraction of the polypeptide is nuclear. Defects in PPP1R13B, the gene which encodes ASPP1, may be a cause of breast cancers. The deduced ASPP1 protein contains 1,090 amino acid residues.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

Specificity :PPP1R13B polyclonal antibody detects endogenous levels of PPP1R13B protein.

BiowMW :~ 119 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B; PPP1R13B; ASPP1; KIAA0771

Immunogen :A synthetic peptide corresponding to residues in Human PPP1R13B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PPP1R13B polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate