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TBC1D2 polyclonal antibody

货号: BS60814

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60814

Product Name :TBC1D2 polyclonal antibody

Swiss-Prot :Q9BYX2

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TBC1D2 polyclonal antibody detects endogenous levels of TBC1D2 protein.

BiowMW :~ 105 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1; BC1D2; PARIS1; PP8997; TBC1D2A

Immunogen :A synthetic peptide corresponding to residues in Human TBC1D2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate