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PTPN21 polyclonal antibody

货号: BS60767

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60767

Product Name :PTPN21 polyclonal antibody

Swiss-Prot :Q16825

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The protein tyrosine phosphatase (PTP) family of proteins are signaling molecules that regulate processes such as cell growth, cell differentiation, oncogenic transformation and the mitotic cycle. PTPN21 (protein tyrosine phosphatase, non-receptor type 21), also known as PTPD1 or PTPRL10, is a 1,174 amino acid member of the PTP family and localizes to both the cytoplasm and the cytoskeleton. Containing one FERM domain and one tyrosine-protein phosphatase domain, PTPN21 functions to catalyze the water-dependent conversion of a protein tyrosine phosphate into a protein tyrosine and a free phosphate and, via this catalytic activity, may be involved in liver regeneration and spermatogenesis. The gene encoding PTPN21 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PTPN21 polyclonal antibody detects endogenous levels of PTPN21 protein.

BiowMW :~ 133 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tyrosine-protein phosphatase non-receptor type 21; Protein-tyrosine phosphatase D1; PTPN21; PTPD1

Immunogen :A synthetic peptide corresponding to residues in Human PTPN21.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PTPN21 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Inhibition of PTPN21 has antitumor effects in glioma by restraining the EGFR/PI3K/AKT pathway

JournalTOXICOLOGY AND APPLIED PHARMACOLOGY

ApplicationWB

IF4.46

SpeciesHuman

PMID35907586