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UNC5A polyclonal antibody

货号: BS60730

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60730

Product Name :UNC5A polyclonal antibody

Swiss-Prot :Q6ZN44

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :UNC5A polyclonal antibody detects endogenous levels of UNC5A protein.

BiowMW :~ 93 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A; UNC5A; KIAA1976; UNC5H1

Immunogen :A synthetic peptide corresponding to residues in Human UNC5A

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of UNC5A polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate