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CATSPER1 polyclonal antibody（KU）

货号: BS60723

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60723

Product Name :CATSPER1 polyclonal antibody（KU）

Swiss-Prot :Q8NEC5

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IP

Application_all :WB: 1:500~1:2000 IP: 1:50~1:200

Background :CatSper is an ion transport protein located on the surface of sperm cells. CatSper (for cation channel of sperm) is vital to cAMP-mediated calcium influx in sperm, sperm motility and fertilization. The gene that encodes CatSper maps to human chromosome 11q12.1. The 686 amino acid protein is a single, six-transmembrane-spanning protein of the voltage- dependent Ca2+ channel four-repeat structure and is expressed exclusively in the testis. In CatSper -/- sperm, neither cAMP nor cGMP elicit a significant Ca2+ influx in both mutant and wild-type sperm. CatSper is localized to the sperm flagellum and CatSper -/- mice show sluggish and less directed movements. CatSper is required to penetrate the egg, but is not required for egg activation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CATSPER1 polyclonal antibody detects endogenous levels of CATSPER1 protein.

BiowMW :~ 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cation channel sperm-associated protein 1; CatSper1; hCatSper; CATSPER1

Immunogen :A synthetic peptide corresponding to residues in Human CATSPER1

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of CATSPER1 polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate Lane2:Hela whole cell lysate Lane3:SP2/0 whole cell lysate