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CDH23 polyclonal antibody

货号: BS60676

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS60676

Product Name :CDH23 polyclonal antibody

Swiss-Prot :Q9H251

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Cadherin-23 represents the first in this family of calcium binding proteins of which mutations in the extracellular calcium binding domain contribute to an inherited disorder, Usher syndrome type 1D (USH1D). Patients with USH1D exhibit congenital sensorineural hearing loss, vestibular dysfunction, and visual impairment due to early onset of retinitis pigmentosa (RP). In the inner ear, cadherin-23 interacts with myosin VIIIa and harmonin to form a functional network duing hair cell differentiation, and in the retina to assemble a supra-molecular complex contributing to the organization of the cytoskeletal matrices of the pre- and post-synaptic region. A number of cadherin-23 splice variants exist in association with various phenotypic expression, indicating that differential mutations result in variable presentation of the disease.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CDH23 polyclonal antibody detects endogenous levels of CDH23 protein.

BiowMW :~ 59 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cadherin-23; Otocadherin; CDH23; KIAA1774; KIAA1812; UNQ1894; PRO4340

Immunogen :A synthetic peptide corresponding to residues in Human CDH23

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CDH23 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）