Product Name :CX3CR1 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Fractalkine, also designated CX3CL1, contains the CX3C motif and is widely ex-pressed in brain and upregulated in endothelial cells in response to inflammatory signals, such as LPS, IL-1, TNF and CD40L. Fractalkine exists both as a membrane-bound form and as a chemotactic soluble form, and binds its cognate receptor, CX3CR1, with high affinity, to induce leukocyte adhesion and migration or chemotactic functions. CX3CR1, previously designated V28 and chemokine β receptor-like 1 (CMKBRL1), is expressed in neutrophils, monocytes, T lymphocytes and several organs including brain. CX3CR1 also functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. CX3CR1 may also be involved in the pathogenesis of atherosclerotic coronary artery disease (CAD) and is considered a potential drug target for therapeutic intervention of endothelium-related inflammatory diseases.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CX3CR1 polyclonal antibody detects endogenous levels of CX3CR1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28; CX3CR1; CMKBRL1; GPR13
Immunogen :A synthetic peptide corresponding to residues in Human CX3CR1
Modification :Unmodification
