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INDO polyclonal antibody

货号: BS60456

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS60456

Product Name :INDO polyclonal antibody

Swiss-Prot :P14902

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Indoleamine 2,3-dioxygenase (IDO) is an IFN-γ inducible enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11. IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immature CD123-positive dentritic cells suppress T cell activity using IDO. IDO-transfected cells co-cultured with T cells reduces T cell proliferation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :INDO polyclonal antibody detects endogenous levels of INDO protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,

Alternative Name :Indoleamine 2,3-dioxygenase 1; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase; IDO1; IDO; INDO

Immunogen :A synthetic peptide corresponding to residues in Human INDO.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of INDO polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate treated with IFNγ(100ug/ml,15mins) Lane2:A549 cell lysate treated with IFNγ(100ug/ml,15mins) Lane3:H9C2 cell lysate treated with IFNγ(100ug/ml,15mins)