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TRPV1 polyclonal antibody

货号: BS60454

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60454

Product Name :TRPV1 polyclonal antibody

Swiss-Prot :Q8NER1

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Vanilloid receptor 1 (VR1), also designated capsaicin receptor, is a nonselective cation channel, structurally related to members of the TRP family of ion channels. VR1 is activated by capsaicin, the active ingredient in chili peppers, by heat and by an increase in protons at sites of infection, inflammation and ischemia. By creating moderately acidic conditions, protons are able to lower the temperature threshold for VR1 activation, thus identifying VR1 as a molecular integrator of chemical and physical stimuli that elicit pain. VR1 is expressed in primary sensory neurons and vagal nerves and activated VR1 induces the influx of cations, particularly Ca2+ and Na+ ions. The vanilloid receptor may also be a molecular target for endogenous anandamide, in addition to the cannabinoid receptors, in the nervous and cardiovascular systems.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TRPV1 polyclonal antibody detects endogenous levels of TRPV1 protein.

BiowMW :~ 94 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Transient receptor potential cation channel subfamily V member 1; TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; TRPV1; VR1

Immunogen :A synthetic peptide corresponding to residues in Human TRPV1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TRPV1 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1

JournalActa Pharmacologica Sinica

ApplicationWB,IHC

IF6.15

SpeciesRat,Mouse

PMID27498772
Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway

JournalAmerican Journal Of Chinese Medicine

ApplicationWB,IHC

IF4.667

SpeciesMouse,Rat

PMID29121795
Acrid and Bitter Chinese Herbs in Decoction Effectively Relieve Lung Inflammation and Regulation of TRPV1/TAS2R14 Channels in a Rat Asthmatic Model

JournalEvidence-based Complementary and Alternative Medicine

ApplicationIF,WB

IF2.65

SpeciesRat

PMID36045655