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SERTAD1 polyclonal antibody

货号: BS60410

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60410

Product Name :SERTAD1 polyclonal antibody

Swiss-Prot :Q9UHV2

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SERTAD1 polyclonal antibody detects endogenous levels of SERTAD1 protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SERTA domain-containing protein 1; CDK4-binding protein p34SEI1; SEI-1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1; SEI1

Immunogen :A synthetic peptide corresponding to residues in Human SERTAD1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SERTAD1 polyclonal antibody at 1:500 dilution Lane1:Jurkat cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate