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CRP polyclonal antibody

货号: BS60395

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60395

Product Name :CRP polyclonal antibody

Swiss-Prot :P02741

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression. SAP binds to a variety of molecules, including autoantigens and chromatin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CRP polyclonal antibody detects endogenous levels of CRP protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C reactive protein; C reactive protein pentraxin related; C-reactive protein(1-205); CRP; CRP; CRP; MGC88244; Pentraxin 1; PTX 1; PTX1;

Immunogen :A synthetic peptide corresponding to residues in Human CRP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CRP polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse liver tissue lysate Lane3:H9C2 cell lysate