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PDCD1 polyclonal antibody

货号: BS60383

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS60383

Product Name :PDCD1 polyclonal antibody

Swiss-Prot :Q15116

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :PDCD1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PDCD1 polyclonal antibody detects endogenous levels of PDCD1 protein.

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,T cell receptor signaling,

Alternative Name :Programmed cell death protein 1; Protein PD-1; hPD-1; CD279; PD1

Immunogen :A synthetic peptide corresponding to residues in Human PDCD1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PDCD1 polyclonal antibody at 1:500 dilution Lane1:HepG2 cell lysate Lane2:Mouse liver tissue lysate Lane3:H9C2 cell lysate