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Profilin-2 polyclonal antibody

货号: BS60364

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60364

Product Name :Profilin-2 polyclonal antibody

Swiss-Prot :P35080

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Profilins (Profilin-1, Profilin-2 and Profilin-3) act as nucleotide exchange factors that use ATP to charge Actin, a process that regulates Actin polymerization by subsequently sequestering the Actin monomer. Profilin-2, also known as PFN2 or PFL, is a 140 amino acid protein that is ubiquitously expressed with highest expression in kidney, brain and skeletal muscle. Like other members of the Profilin family, Profilin-2 functions as an Actin monomer-binding protein that influences the structure of the cytoskeleton by regulating Actin polymerization in response to extracellular signals. High levels of Profilin-2 inhibit Actin polymerization, while lower levels enhance Actin polymerization, suggesting that the expression of Profilin-2 is regulated by the need for polymerization within the cell. Two isoforms of Profilin-2 exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Profilin-2 polyclonal antibody detects endogenous levels of Profilin-2 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Profilin2; Profilin 2; Profilin II; PFN2

Immunogen :A synthetic peptide corresponding to residues in Human Profilin-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Profilin-2 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat skeletal muscle tissue lysate

Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Biomarkers of Kidney Cancer

JournalProteomics Clinical Applications

ApplicationWB,IHC

IF3.494

SpeciesHuman

PMID28975715
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury

JournalFaseb Journal

ApplicationIF

IF5.391

SpeciesMouse

PMID29879372