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p22-phox polyclonal antibody

货号: BS60290

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60290

Product Name :p22-phox polyclonal antibody

Swiss-Prot :P13498

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane, where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p22-phox polyclonal antibody detects endogenous levels of p22-phox protein.

BiowMW :~ 210 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox; CYBA

Immunogen :A synthetic peptide corresponding to residues in Human p22-phox.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of p22-phox polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate

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