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RGS4 polyclonal antibody

货号: BS60231

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60231

Product Name :RGS4 polyclonal antibody

Swiss-Prot :P49798

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their α subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four Gα GTPase-activating proteins (GAPs) have been identified and are designated RGS1 (regulator of G protein signaling), RGS4, RGS10 and GAIP (Gα-interacting protein). Each of these proteins has been shown to deactivate specific Gα isoforms by increasing the rate at which they convert GTP to GDP. RGS1, RGS4 and GAIP bind tightly to and exhibit GAP activity towards Gα i, Gα o and Gα t, but not Gα s. RGS10 increases the GTP hydrolytic activity of several members of the Gα i subfamily including Gα i-3, Gα z, and Gα o.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RGS4 polyclonal antibody detects endogenous levels of RGS4 protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Regulator of G-protein signaling 4; RGP4; RGS-4

Immunogen :A synthetic peptide corresponding to residues in Human RGS4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RGS4 polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate