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RGS20 polyclonal antibody

货号: BS60230

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60230

Product Name :RGS20 polyclonal antibody

Swiss-Prot :O76081

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a subunits) thereby driving G proteins into their inactive GDP-bound form. RGS20 is expressed exclusively in brain, with highest levels in the caudate nucleus and temporal lobe. RGS20 belongs to the RZ subfamily because it is highly selectivie for the az subunit on G proteins. However, if protein kinase C phosphorylates the az subunit, the G protein is much less susceptible to RGS20 action. RGS20 directly interacts with the microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) and blocks its ability to induce microtubule disassmebly.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RGS20 polyclonal antibody detects endogenous levels of RGS20 protein.

BiowMW :~ 30 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Regulator of G-protein signaling 20; Gz-selective GTPase-activating protein; G(z)GAP; Gz-GAP; Regulator of G-protein signaling Z1; Regulator of Gz-selective protein signaling 1; RGSZ1; ZGAP1

Immunogen :A synthetic peptide corresponding to residues in Human RGS20.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RGS20 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:H9C2 whole cell lysate