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RASA4 polyclonal antibody

货号: BS60215

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS60215

Product Name :RASA4 polyclonal antibody

Swiss-Prot :O43374

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :RASA4 (ras GTPase-activating protein 4) is an 803 amino acid member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogenactivated protein kinase pathway in response to Ca2+. Stimuli that increase intracellular Ca2+ levels result in the translocation of the RASA4 protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth and differentiation. Containing 21 exons and spanning 35 kb of genomic DNA, RASA4 includes one Btk-type zinc finger, two C2 domains, one PH domain and one Ras-GAP domain.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RASA4 polyclonal antibody detects endogenous levels of RASA4 protein.

BiowMW :~ 85, 90 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ras GTPase-activating protein 4; Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2; CAPRI; GAPL; KIAA0538

Immunogen :A synthetic peptide corresponding to residues in Human RASA4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RASA4 (F157) pAb at 1:500 dilution Lane1:3T3-L1 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug)