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MAL polyclonal antibody

货号: BS60179

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60179

Product Name :MAL polyclonal antibody

Swiss-Prot :P21145

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The MAL-SRF interaction displays the predicted properties of a Rho-regulated SRF cofactor. MAL is predominantly cytoplasmic in serum-starved cells, but accumulates in the nucleus following serum stimulation. Activation of the Rho-actin signaling pathway is necessary and sufficient to promote MAL nuclear accumulation. MAL N-terminal sequences, including two RPEL motifs, are required for the response to signaling, while other regions mediate its nuclear export (or cytoplasmic retention) and nuclear import. MAL associates with unpolymerized actin through its RPEL motifs. Constitutively cytoplasmic MAL derivatives interfere with MAL redistribution and Rho-actin signaling to SRF.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MAL pAb detects endogenous levels of MAL protein.

BiowMW :~ 16 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein; MAL

Immunogen :Synthetic peptide, corresponding Human MAL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MAL pAb at 1:500 dilution Lane1:Myla2059 whole cell lysate(40ug) Lane2:HuT78 whole cell lysate(40ug) Lane3:The Spleen tissue lysate of Rat(40ug) Lane4:The Spleen tissue lysate of Mouse(40ug) Lane5:AML-12 whole cell lysate(40ug) Lane6:CT26 whole cell lysate(40ug)