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UBR2 polyclonal antibody

货号: BS60150

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60150

Product Name :UBR2 polyclonal antibody

Swiss-Prot :Q8IWV8

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :UBR2 polyclonal antibody detects endogenous levels of UBR2 protein.

BiowMW :~ 200 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase UBR2; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II; C6orf133; KIAA0349

Immunogen :A synthetic peptide corresponding to residues in Human UBR2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of UBR2 polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell‐Exosome Promoted Gastric Cancer Progression via Wnt/β‐Catenin Pathway

JournalStem Cells

ApplicationWB,IHC

IF6.022

SpeciesMouse

PMID28895255
Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesMouse

PMID32186775