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VHL polyclonal antibody

货号: BS60046

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60046

Product Name :VHL polyclonal antibody

Swiss-Prot :P40337

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VHL polyclonal antibody detects endogenous levels of VHL protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Hypoxia Signaling,

Alternative Name :Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL; VHL

Immunogen :A synthetic peptide corresponding to residues in Human VHL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of VHL polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:A549 whole cell lysate Lane3:Rat brain tissue lysate