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LATS1 polyclonal antibody

货号: BS60042

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60042

Product Name :LATS1 polyclonal antibody

Swiss-Prot :O95835

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Drosophila tumor suppressor protein lats (for large tumor suppressor) is a putative protein kinase that shares homology with three proteins in Neurospora and budding yeast that are involved in cell cycle and growth regulation: S. cerevisiae Dbf2 and Dbf20, and Neurospora cot-1. Mosaic screens in Drosophila have identified the lats gene as a tumor suppressor in this species. The human homolog, designated LATS1, was shown to inhibit tumor growth in lats-deficient Drosophila. Human LATS1 binds to Cdc2 in early mitosis and appears to negatively regulate the kinase activity of Cdc2. LATS1-deficient mice are highly sensitive to carcinogenic treatments and develop soft-tissue sarcomas and ovarian stromal cell tumors, indicating a role for mammalian LATS1 in tumorigenesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LATS1 polyclonal antibody detects endogenous levels of LATS1 protein.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :hippo Signaling,

Alternative Name :Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; WARTS

Immunogen :A synthetic peptide corresponding to residues in Human LATS1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of LATS1 pAb at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug) Lane5:A2780 whole cell lysate(40ug) Lane6:The Embryo tissue lysate of Mouse(40ug)