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CDKL5 polyclonal antibody

货号: BS60038

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60038

Product Name :CDKL5 polyclonal antibody

Swiss-Prot :O76039

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CDKL5 polyclonal antibody detects endogenous levels of CDKL5 protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cyclin-dependent kinase-like 5; Serine/threonine-protein kinase 9; STK9

Immunogen :A synthetic peptide corresponding to residues in Human CDKL5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CDKL5 polyclonal antibody at 1:500 dilution Lane1:HEK293Twhole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate