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TERT polyclonal antibody

货号: BS60032

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60032

Product Name :TERT polyclonal antibody

Swiss-Prot :O14746

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Telomerase is an RNA-dependent DNA polymerase that catalyzes the addition of telomeric repeat sequences to chromosome ends. In most human somatic cells, telomerase activity is undetectable, and telomeres shorten with successive cell divisions. However, telomerase activity is detectable in immortal cells and in many human tumors. Two candidate mammalian telomerase proteins have been cloned. Human TP1 (for telomerase-associated protein 1), also designated TLP1 in rat (for telomerase protein component 1), is homologous to the Tetrahymena p80 telomerase protein and has been shown to interact with mammalian telomerase RNA. Human TERT (for telomerase reverse transcriptase), also designated hEST2 (for ever shorter telomeres), is homologous to the p123 telomerase protein from Euplotes and to the yeast Est2 protein. Expression of TERT mRNA has been shown to correlate with telomerase activity in various cell lines.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TERT polyclonal antibody detects endogenous levels of TERT protein.

BiowMW :~ 127 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2; TERT; EST2; TCS1; TRT

Immunogen :A synthetic peptide corresponding to residues in Human TERT.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TERT polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Stromal cell‐derived factor‐1α prevents endothelial progenitor cells senescence and enhances re‐endothelialization of injured arteries via human telomerase reverse transcriptase

JournalCell Biology International

ApplicationWB

IF2.571

SpeciesHuman

PMID25820929
Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID27840978