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TNFα-IP8 polyclonal antibody

货号: BS5965

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5965

Product Name :TNFα-IP8 polyclonal antibody

Swiss-Prot :O95379

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :TNFα-IP 8 (tumor necrosis factor, α-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFα-IP 8 by TNF is dependent on the activation of NFκB. TNFα-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFα-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFα-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFα-IP 8 is present as three isoforms produced by alternative splicing.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TNFα-IP8 polyclonal antibody detects endogenous levels of TNFα-IP8 protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; MDC3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; SCC S2; SCCS2; TNF-induced protein GG2-1; TNFAIP8; TNFα IP8; TNFαIP8; TNFα-IP 8

Immunogen :Synthetic peptide, corresponding to amino acids 71-116 of Human TNFα-IP83.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TNFα-IP8 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate