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TCP-1ζ polyclonal antibody

货号: BS5959

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS5959

Product Name :TCP-1ζ polyclonal antibody

Swiss-Prot :P40227

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The protein TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT of eukaryotic cytosol is composed of eight different subunit species, TCP-1 α, β, γ, δ, ε, ζ, η and θ, each encoded by a different gene. Two ζ subunits have been described: TCP-1 ζ (also designated TCP-1 ζ1) and TCP-1 ζ2. TCP-1 subunits are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Sequences homologous to TCP-1 have been isolated in several other species, and the yeast TCP-1 has been shown to encode a molecular chaperone for Actin and Tubulin. TCP-1 found in mammalian cells and yeast plays an important role in the folding of cytosolic proteins.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TCP-1ζ polyclonal antibody detects endogenous levels of TCP-1ζ protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-complex protein 1 subunit zeta; TCP-1-zeta; Acute morphine dependence-related protein 2; CCT-zeta-1; HTR3; Tcp20; CCT6A; CCT6; CCTZ; TCP1ζ; TCP 1ζ; TCP1-ζ; TCP-1-ζ; CCT-ζ-1; CCTζ-1; CCT-ζ1; CCTζ1;

Immunogen :Synthetic peptide, corresponding to amino acids 216-261 of Human TCP-1ζ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TCP-1ζ polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate

Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis

JournalOncotarget

ApplicationIHC

IF0

SpeciesHuman,Rat

PMID26556873