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RORγ polyclonal antibody

货号: BS5915

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5915

Product Name :RORγ polyclonal antibody

Swiss-Prot :P51449

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The nuclear orphan receptors RORα and RORγ are members of the nuclear hormone receptor superfamily. This family acts by directly associating with DNA sequences known as hormone response elements (HREs) and typically binds DNA as either homo- or heterodimers. RORα and RORγ are unique in that they bind DNA as monomers. RORα has multiple isoforms that share common DNA- and putative ligand-binding domains, but differ in their aminoterminal domains, which are generated by alternative RNA processing. RORγ comprises a 560 amino acid protein that shares 50% amino acid identity with RORα and is most highly expressed in skeletal muscle. Although these proteins are considered “orphan receptors,” due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RORγ polyclonal antibody detects endogenous levels of RORγ protein.

BiowMW :~ 63 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; Retinoid-related orphan receptor-gamma; RORC; NR1F3; RORG; RZRG

Immunogen :Synthetic peptide, corresponding to amino acids 114-159 of Human RORγ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of RORγ polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate

Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice

JournalEvidence-based Complementary and Alternative Medicine

ApplicationWB

IF2.629

SpeciesMouse

PMID34194525
Ginkgo biloba extract promotes Treg differentiation to ameliorate ischemic stroke via inhibition of HIF-1α/HK2 pathway

JournalPHYTOTHERAPY RESEARCH

ApplicationIF

IF7.2

SpeciesMouse

PMID37655539